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Secomb, PhD CONTENTS INTRODUCTION Optlon EFFECTS OF CELLULAR DRUG Ibnary DRUG EXPOSURE AND HOST TOXICITY OPTIMIZATION OF INTRAVENOUS DELIVERY CARRIERS FOR INTRAVENOUS ADMINISTRATION REGIONAL DELIVERY MODALITIES FUTURE DIRECTIONS AND CONCLUSIONS ACKNOWLEDGMENTS REFERENCES 3 1. Most of the drugs in this table have first-pass metabolism that is greater than 50 in normal subjects but is substantially reduced when liver function is impaired.
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